Title : Effect of doxorubicin on telomerase activity and apoptotic gene expression in doxorubicin-resistant and -sensitive MCF-7 cells: an experimental study.

Pub. Date : 2008

PMID : 18560228






2 Functional Relationships(s)
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1 METHODS: Doxorubicin-resistant MCF-7/R was developed from sensitive MCF-7 breast carcinoma cell line and acquired resistance was demonstrated by XTT and mRNA analysis of MDR1 and MRP1 genes. Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens
2 RESULTS: Doxorubicin-selected MCF-7 cells were 107-fold resistant to the drug and overexpress MDR1 and MRP1 genes. Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens