Title : Interaction of CD44 and hyaluronic acid enhances biliary epithelial proliferation in cholestatic livers.

Pub. Date : 2008 Aug

PMID : 18556418






4 Functional Relationships(s)
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1 Cell culture experiments were employed to determine whether hyaluronan can regulate cholangiocyte growth through interacting with adhesion molecule CD44. Hyaluronic Acid CD44 molecule (Indian blood group) Rattus norvegicus
2 CD44-positive biliary epithelia lining the intrahepatic bile ducts were geographically associated with extracellular hyaluronan accumulated in the portal tracts of the livers, suggesting a role for CD44 and hyaluronan in the development of biliary proliferation. Hyaluronic Acid CD44 molecule (Indian blood group) Rattus norvegicus
3 CD44-positive biliary epithelia lining the intrahepatic bile ducts were geographically associated with extracellular hyaluronan accumulated in the portal tracts of the livers, suggesting a role for CD44 and hyaluronan in the development of biliary proliferation. Hyaluronic Acid CD44 molecule (Indian blood group) Rattus norvegicus
4 CD44-hyaluronan interaction, by enhancing biliary proliferation, may play a pathogenic role in the development of cholestatic liver diseases. Hyaluronic Acid CD44 molecule (Indian blood group) Rattus norvegicus