Title : Aldosterone modifies hemostasis via upregulation of the protein-C receptor in human vascular endothelium.

Pub. Date : 2008 Aug 22

PMID : 18555797






1 Functional Relationships(s)
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1 When aldosterone-treated HBMEC were incubated with the activated protein C (APC), the partial thromboplastin clotting time (aPTT) increased 2.5-fold over control, from 10 to 25 s. The MCR antagonists aldactone and eplerenone reduced the basal coagulation time in untreated cells to 33.5% and 42% of the control, respectively. Eplerenone nuclear receptor subfamily 3 group C member 2 Homo sapiens