Title : Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.

Pub. Date : 2008 Jul

PMID : 18551038






1 Functional Relationships(s)
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1 Response to the antifolate methotrexate (MTX) may be modified in 677TT individuals because MTHFR converts nonmethylated folates, used for thymidine and purine synthesis, to 5-methyltetrahydrofolate, used in homocysteine remethylation to methionine. Methionine methylenetetrahydrofolate reductase Mus musculus