Title : The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts.

Pub. Date : 2008 Jul

PMID : 18550580






1 Functional Relationships(s)
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Protein Name
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1 Direct covalent complex formation between the CrA-PdG adduct and Top1 is detectable after reduction with sodium cyanoborohydride, which is consistent with the formation of a Schiff base between Top1 and the ring open aldehyde form of the adduct. sodium cyanoborohydride myotubularin related protein 11 Homo sapiens