Title : Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors.

Pub. Date : 2009 Feb

PMID : 18550228






1 Functional Relationships(s)
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1 All of the new compounds prepared showed high AChE inhibitory activities, with compound 3e that has an N-hexyl-benzyl piperidine substituent on the nitrogen atom reaching the best inhibitory activity for AChE (IC(50)=5.62 nM). Nitrogen acetylcholinesterase (Cartwright blood group) Homo sapiens