Title : Activation of PKC epsilon induces lactotroph proliferation through ERK1/2 in response to phorbol ester.

Pub. Date : 2008 Jul 16

PMID : 18534741






2 Functional Relationships(s)
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1 In primary pituitary cultures, the activation of protein kinase C (PKC) by PMA for 15 min stimulated lactotroph proliferation; whereas a prolonged activation for 3-8h diminished this proliferative effect. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
2 The use of PMA for 15 min-activated PKCepsilon and ERK1/2, whereas incubation with PMA for 3 h induced PKCalpha activation and attenuated the PMA-triggered phosphorylation of ERK1/2. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens