Pub. Date : 2008 Jun 15
PMID : 18523246
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 2 | In this study, we determined whether the lysophospholipids, i.e., LPC and sphingosylphosphorylcholine (SPC), modulate the ATP-induced release and processing of IL-1beta mediated by P2X7R in mouse MG6 microglial cells. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 3 | However, these lysophospholipids inhibited ATP-induced caspase-1 activation that is usually followed by the release of mIL-1beta. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 4 | Conversely, ATP inhibited the release of pro-IL-1beta and mIL-1beta induced by LPC/SPC. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 5 | Conversely, ATP inhibited the release of pro-IL-1beta and mIL-1beta induced by LPC/SPC. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 6 | This suggests that lysophospholipids and ATP mutually suppressed each function to release IL-1beta. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 7 | In addition, the microtubule inhibitor colchicine inhibited ATP-induced release of mIL-1beta similar to that of LPC and SPC. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 8 | This suggests that the impairment of the microtubule reassembly may be associated with the inhibitory effects of LPC/SPC on ATP-induced mIL-1beta release. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 9 | Mutual suppression by ATP and LPC/SPC on the maturation of IL-1beta was observed in LPS-primed primary microglia. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |