Title : Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression.

Pub. Date : 2008 Aug

PMID : 18505831






3 Functional Relationships(s)
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Protein Name
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1 Sodium arsenite augments hepatic SHP mRNA levels in an AMP-activated protein kinase (AMPK)-dependent manner. sodium arsenite protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens
2 Sodium arsenite activated AMPK and was shown to perturb cellular ATP levels. sodium arsenite protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens
3 Results from our study suggest that sodium arsenite induces SHP via AMPK to inhibit the expression of hepatic gluconeogenic genes and also provide us with a novel molecular mechanism of arsenite-mediated regulation of hepatic glucose homeostasis. sodium arsenite protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens