Pub. Date : 2008 Sep 25
PMID : 18501341
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | One of the therapeutic approaches to organophosphate poisoning is to reactivate AChE with site-directed nucleophiles such as oximes. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | We tested oximes varying in the type of ring (pyridinium and/or imidazolium), the length and type of the linker between rings, and in the position of the oxime group on the ring to find more effective oximes to reactivate tabun-inhibited human erythrocyte AChE. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Since the reactivating efficacy of the oximes in vitro corresponded to their therapeutic efficacy in vivo, it seems that pharmacological effect of these oximes is indeed primarily related to the reactivation of tabun-phosphorylated AChE. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | Since the reactivating efficacy of the oximes in vitro corresponded to their therapeutic efficacy in vivo, it seems that pharmacological effect of these oximes is indeed primarily related to the reactivation of tabun-phosphorylated AChE. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |