Pub. Date : 2008 Jul
PMID : 18492692
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FK506 removed FKBP12 from its binding to the TGF-beta-receptor. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 2 | CONCLUSIONS: Our study shows that most chronic lymphocytic leukemia cells escape the homeostatic control of TGF-beta and that FK506 restores the TGF-beta signal in a proportion of non-responsive samples. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 3 | We demonstrated that FK506 activates TGF-beta receptor I kinase activity in chronic lymphocytic leukemia, which transduces apoptosis by a mitochondrial-dependent pathway. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |