Pub. Date : 2008 Jul
PMID : 18487435
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Therefore, cyclic AMP increases the expression of alpha(2C)-ARs in cutaneous VSMCs by activating a novel Rap1 signaling pathway, mediated by the activation of JNK, AP-1, and the subsequent transcriptional activation of the alpha(2C)-AR gene. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |