Title : Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death.

Pub. Date : 2008 May 15

PMID : 18483381






1 Functional Relationships(s)
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1 RESULTS: In this report, we show that the HDIs trichostatin A, sodium butyrate, and low nanomolar doses of LAQ824 combined with the glycolysis inhibitor 2-deoxy-d-glucose induce strong apoptosis in cancer cell lines of brain, breast, and cervix in a p53-independent manner. trichostatin A tumor protein p53 Homo sapiens