Pub. Date : 2008 May 13
PMID : 18477395
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intriguingly, the deletion of the C-terminal proline-rich region of ALIX prevented detectable binding to p6. | Proline | programmed cell death 6 interacting protein | Homo sapiens |
| 2 | In contrast, a four-amino acid deletion in the central hinge region of p6 increased its association with ALIX as shown by its ability to bind to ALIX lacking the proline rich domain. | Proline | programmed cell death 6 interacting protein | Homo sapiens |
| 3 | Altogether, our data support a model where the C-terminal proline-rich domain of ALIX allows the access of its binding site to p6 by alleviating a conformational constraint resulting from the presence of the central p6 hinge. | Proline | programmed cell death 6 interacting protein | Homo sapiens |