Title : The LPS-induced neutrophil recruitment into rat air pouches is mediated by TNFalpha: likely macrophage origin.

Pub. Date : 1997

PMID : 18472868






1 Functional Relationships(s)
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1 Dexamethasone (0.05-5 mug) and cycloheximide (6 ng), injected 2 h before LPS into the pouches, inhibited the neutrophil recruitment and the generation of the TNFalpha-like activity, while the H1-receptor antagonist mepyramine (1 and 4 mg/kg, i.p., 0.5 h before LPS) and the PAF-receptor antagonist WEB 2170 (0.05 and 1 mg/kg, i.p., 0.5 h before LPS) had no effect. Cycloheximide tumor necrosis factor Rattus norvegicus