Pub. Date : 2008 Dec
PMID : 18468633
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of doxorubicin on MEK-ERK signaling predicts its efficacy in HCC. | Doxorubicin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | At early time points (30 min) after DOX treatment of Hep3B cells, MEK activity was unchanged at low doses and decreased at higher doses; after 24 h, phospho-ERK levels increased at higher doses. | Doxorubicin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Contrarily, in HepG2 cells, DOX caused a sustained, dose-dependent increase in phospho-ERK levels at early and late time points. | Doxorubicin | mitogen-activated protein kinase 1 | Homo sapiens |