Title : Protein kinase C regulates the synthesis of platelet-activating factor by human monocytes.

Pub. Date : 1991 Feb

PMID : 1846746






3 Functional Relationships(s)
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1 Sphingosine also blocked PAF synthesis in response to the calcium ionophore A23187 and opsonized zymosan particles by specific inhibition of PKC. Zymosan proline rich transmembrane protein 2 Homo sapiens
2 Two other PKC inhibitors, stearylamine and staurosporine, also blocked PAF synthesis following A23187 or opsonized zymosan stimulation. Zymosan proline rich transmembrane protein 2 Homo sapiens
3 These experiments demonstrated that PKC activation was required for PAF synthesis in response to the calcium signal generated by A23187 or a receptor-mediated agonist, opsonized zymosan. Zymosan proline rich transmembrane protein 2 Homo sapiens