Title : Role of cyclic AMP and polypeptide growth regulators in growth inhibition by interferon in PC-3 cells.

Pub. Date : 1991

PMID : 1846237






3 Functional Relationships(s)
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1 Participation of growth factors and intracellular cAMP in direct antiproliferative action of interferon alpha (IFN-alpha) was investigated in PC-3 human prostate carcinoma cell line. Cyclic AMP interferon alpha 1 Homo sapiens
2 On the other hand, IFN-alpha increased intracellular cAMP concentration about 20-fold. Cyclic AMP interferon alpha 1 Homo sapiens
3 These indicated that direct antiproliferative effect of IFN-alpha on PC-3 cells was at least partly mediated by cAMP, and that neither growth factors nor a growth inhibitor participated in the action of IFN-alpha. Cyclic AMP interferon alpha 1 Homo sapiens