Title : CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels.

Pub. Date : 2008 Aug

PMID : 18458892






2 Functional Relationships(s)
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1 Efavirenz is an inducer of CYP3A, whereas the ritonavir-boosted regimens are net inhibitors of CYP3A. efavirenz cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CONCLUSION: Changes in plasma 4beta-hydroxycholesterol following the initiation of efavirenz- or atazanavir/ritonavir-based antiretroviral therapy reflected the respective net increase and decrease of CYP3A activity of these regimens. efavirenz cytochrome P450 family 3 subfamily A member 4 Homo sapiens