Pub. Date : 2008 Sep
PMID : 18458149
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Concomitantly, palmitate activated and EPA abolished both mRNA and nuclear protein of SREBP-1c, accompanied by reciprocal changes of SREBP-1c target genes such as insulin receptor substrate-2 (IRS-2) and granuphilin. | Eicosapentaenoic Acid | sterol regulatory element binding transcription factor 1 | Mus musculus |
| 2 | CONCLUSIONS: SREBP-1c plays a dominant role in palmitate-mediated insulin secretion defect, and EPA prevents it through SREBP-1c inhibition, implicating a therapeutic potential for treating diabetes related to lipotoxicity. | Eicosapentaenoic Acid | sterol regulatory element binding transcription factor 1 | Mus musculus |