Title : MEK inhibition induces caspases activation, differentiation blockade and PML/RARalpha degradation in acute promyelocytic leukaemia.

Pub. Date : 2008 Jul

PMID : 18445086






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PML/RARalpha is directly targeted by all-trans-retinoic acid (ATRA), which degrades the oncoprotein and induces complete remission of malignancies. Tretinoin PML nuclear body scaffold Homo sapiens
2 PML/RARalpha is directly targeted by all-trans-retinoic acid (ATRA), which degrades the oncoprotein and induces complete remission of malignancies. Tretinoin PML nuclear body scaffold Homo sapiens