Title : Microbial biotin protein ligases aid in understanding holocarboxylase synthetase deficiency.

Pub. Date : 2008 Jul-Aug

PMID : 18442489






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The attachment of biotin onto the biotin-dependent enzymes is catalysed by biotin protein ligase (BPL), also known as holocarboxylase synthase HCS in mammals. Biotin holocarboxylase synthetase Homo sapiens
2 The attachment of biotin onto the biotin-dependent enzymes is catalysed by biotin protein ligase (BPL), also known as holocarboxylase synthase HCS in mammals. Biotin holocarboxylase synthetase Homo sapiens
3 All mammalian biotin-enzymes are post-translationally biotinylated, and therefore activated, through the action of a single HCS. Biotin holocarboxylase synthetase Homo sapiens
4 Defects in biotin metabolism, including HCS, give rise to multiple carboxylase deficiency (MCD). Biotin holocarboxylase synthetase Homo sapiens