Title : Activation of C-transactivation domain is essential for optimal HIF-1 alpha-mediated transcriptional and angiogenic effects.

Pub. Date : 2008 May

PMID : 18440561






1 Functional Relationships(s)
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1 For therapeutic angiogenesis purposes, HIF-1 alpha stabilization was previously achieved by either deleting its oxygen-dependent degradation domains, or introducing two proline point mutations at residues P402 and P564. Proline hypoxia inducible factor 1 subunit alpha Homo sapiens