Title : Studies with leucine, beta-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion.

Pub. Date : 2008 Jul-Aug

PMID : 18439432






1 Functional Relationships(s)
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1 In ATP citrate lyase-deficient INS-1 cells, which are unable to convert citrate into cytosolic acetyl-CoA, insulin release by BCH was decreased and adding beta-hydroxybutyrate or alpha-ketoisocaproate, which increases mitochondrial acetoacetate, normalized BCH-induced insulin release. 3-Hydroxybutyric Acid ATP citrate lyase Rattus norvegicus