Title : Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4.

Pub. Date : 2008 Sep

PMID : 18431572






1 Functional Relationships(s)
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1 In human liver microsomal preparations, eribulin suppressed the activities of CYP3A4-mediated testosterone and midazolam hydroxylation with an apparent K (i) of approximately 20 microM. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens