Pub. Date : 2008 Jun
PMID : 18423603
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner. | Curcumin | H3 histone pseudogene 16 | Homo sapiens |
| 2 | Several studies report that curcumin inhibits cancer cell proliferation and induces apoptosis in cancer cells through p21-mediated cell cycle arrest. | Curcumin | H3 histone pseudogene 16 | Homo sapiens |
| 3 | In this study, we determined whether curcumin-induced cytotoxicity in cultures of HCT-116 human colon cancer cells was dependent on p21 status. | Curcumin | H3 histone pseudogene 16 | Homo sapiens |
| 4 | Moreover, an equivalent cytotoxic effect by curcumin was observed in both p21(+/+) and p21(-/-)HCT-116 cells, indicating that curcumin-induced cytotoxicity was p21-independent. | Curcumin | H3 histone pseudogene 16 | Homo sapiens |
| 5 | Moreover, an equivalent cytotoxic effect by curcumin was observed in both p21(+/+) and p21(-/-)HCT-116 cells, indicating that curcumin-induced cytotoxicity was p21-independent. | Curcumin | H3 histone pseudogene 16 | Homo sapiens |
| 6 | Moreover, an equivalent cytotoxic effect by curcumin was observed in both p21(+/+) and p21(-/-)HCT-116 cells, indicating that curcumin-induced cytotoxicity was p21-independent. | Curcumin | H3 histone pseudogene 16 | Homo sapiens |
| 7 | Western blot analysis showed that cell death in curcumin-treated cultures of p21(+/+) and p21(-/-) HCT-116 cells was associated with a reduction in pro-caspase-3 and PARP-1 cleavage, which are indicative of apoptosis. | Curcumin | H3 histone pseudogene 16 | Homo sapiens |
| 8 | Western blot analysis showed that cell death in curcumin-treated cultures of p21(+/+) and p21(-/-) HCT-116 cells was associated with a reduction in pro-caspase-3 and PARP-1 cleavage, which are indicative of apoptosis. | Curcumin | H3 histone pseudogene 16 | Homo sapiens |