Pub. Date : 2008
PMID : 18418675
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Spinocerebellar ataxia type 7 (SCA7) is unique among CAG/polyglutamine (polyQ) repeat diseases due to dramatic intergenerational instability in repeat length and an associated cone-rod dystrophy retinal degeneration phenotype. | polyglutamine | ataxin 7 | Homo sapiens |
| 2 | Spinocerebellar ataxia type 7 (SCA7) is unique among CAG/polyglutamine (polyQ) repeat diseases due to dramatic intergenerational instability in repeat length and an associated cone-rod dystrophy retinal degeneration phenotype. | polyglutamine | ataxin 7 | Homo sapiens |
| 3 | Spinocerebellar ataxia type 7 (SCA7) is unique among CAG/polyglutamine (polyQ) repeat diseases due to dramatic intergenerational instability in repeat length and an associated cone-rod dystrophy retinal degeneration phenotype. | polyglutamine | ataxin 7 | Homo sapiens |
| 4 | Spinocerebellar ataxia type 7 (SCA7) is unique among CAG/polyglutamine (polyQ) repeat diseases due to dramatic intergenerational instability in repeat length and an associated cone-rod dystrophy retinal degeneration phenotype. | polyglutamine | ataxin 7 | Homo sapiens |
| 5 | SCA7 is caused by a polyQ expansion in the protein ataxin-7. | polyglutamine | ataxin 7 | Homo sapiens |
| 6 | SCA7 is caused by a polyQ expansion in the protein ataxin-7. | polyglutamine | ataxin 7 | Homo sapiens |
| 7 | Several potential mechanisms for the molecular pathogenesis of polyQ-expanded ataxin-7 have been suggested. | polyglutamine | ataxin 7 | Homo sapiens |
| 8 | These include, but are not limited to, alteration of endogenous ataxin-7 function, abnormal processing and stability of polyQ ataxin-7, and alteration of transcriptional regulation via interaction of polyQ-expanded ataxin-7 with other transcriptional regulators. | polyglutamine | ataxin 7 | Homo sapiens |
| 9 | These include, but are not limited to, alteration of endogenous ataxin-7 function, abnormal processing and stability of polyQ ataxin-7, and alteration of transcriptional regulation via interaction of polyQ-expanded ataxin-7 with other transcriptional regulators. | polyglutamine | ataxin 7 | Homo sapiens |
| 10 | PolyQ-expanded ataxin-7 can cause non-cell autonomous neurodegeneration in cerebellar Purkinje cells. | polyglutamine | ataxin 7 | Homo sapiens |