Title : p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1.

Pub. Date : 2008 May 1

PMID : 18418051






1 Functional Relationships(s)
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1 Using reporter assays and Electrophoretic Mobility Shift Assays (EMSA), our findings suggest that TAp73-mediated activation of the p21(cip/waf), 14-3-3sigma and Bax gene promoters is abrogated by expressed PLK1 for which post-translational modification of TAp73 Thr-27 appears to be a key step in MCF7 cells. Threonine H3 histone pseudogene 16 Homo sapiens