Title : Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras.

Pub. Date : 2008 May

PMID : 18410586






2 Functional Relationships(s)
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1 It was found that melatonin strongly attenuated H(2)O(2)-induced activation of the ERK1/2 and p38 MAP kinases, as well as several of their downstream targets. Hydrogen Peroxide mitogen activated protein kinase 14 Rattus norvegicus
2 Upregulation of ERK1/2, p38, and Akt signaling by H(2)O(2) was accompanied by activation of Ras, an effect that was blocked by melatonin. Hydrogen Peroxide mitogen activated protein kinase 14 Rattus norvegicus