Title : Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras.

Pub. Date : 2008 May

PMID : 18410586






4 Functional Relationships(s)
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1 In the present study, the effect of melatonin treatment on the hydrogen peroxide (H(2)O(2))-induced activation of the mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways was assessed in H4IIE hepatoma cells. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus
2 In the present study, the effect of melatonin treatment on the hydrogen peroxide (H(2)O(2))-induced activation of the mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways was assessed in H4IIE hepatoma cells. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus
3 It was found that melatonin strongly attenuated H(2)O(2)-induced activation of the ERK1/2 and p38 MAP kinases, as well as several of their downstream targets. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus
4 Upregulation of ERK1/2, p38, and Akt signaling by H(2)O(2) was accompanied by activation of Ras, an effect that was blocked by melatonin. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus