Title : Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome.

Pub. Date : 2008 Jun

PMID : 18390821






3 Functional Relationships(s)
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1 In lean pigs, capsaicin, a TRPV1 agonist, relaxed arteries in a dose-dependent manner (EC50 = 116 +/- 41 nM). Capsaicin transient receptor potential cation channel subfamily V member 1 Sus scrofa
2 Capsaicin-induced relaxation was blocked by the TRPV1 antagonist capsazepine, endothelial denudation, inhibition of nitric oxide synthase, and K+ channel antagonists. Capsaicin transient receptor potential cation channel subfamily V member 1 Sus scrofa
3 Impaired capsaicin-induced vasodilation in the metabolic syndrome is associated with decreased expression of TRPV1 and cation influx. Capsaicin transient receptor potential cation channel subfamily V member 1 Sus scrofa