Pub. Date : 2008 Apr
PMID : 18389497
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Tsc1(GFAP)CKO mice and littermate control animals were treated with rapamycin or vehicle starting at postnatal day 14 (early treatment) or 6 weeks of age (late treatment), corresponding to times before and after onset of neurological abnormalities in Tsc1(GFAP)CKO mice. | Sirolimus | TSC complex subunit 1 | Mus musculus |
| 2 | RESULTS: Early treatment with rapamycin prevented the development of epilepsy and premature death observed in vehicle-treated Tsc1(GFAP)CKO mice. | Sirolimus | TSC complex subunit 1 | Mus musculus |
| 3 | Late treatment with rapamycin suppressed seizures and prolonged survival in Tsc1(GFAP)CKO mice that had already developed epilepsy. | Sirolimus | TSC complex subunit 1 | Mus musculus |
| 4 | INTERPRETATION: Rapamycin has strong efficacy for preventing seizures and prolonging survival in Tsc1(GFAP)CKO mice. | Sirolimus | TSC complex subunit 1 | Mus musculus |