Pub. Date : 2008 Jul 1
PMID : 18387645
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | JWA is required for arsenic trioxide induced apoptosis in HeLa and MCF-7 cells via reactive oxygen species and mitochondria linked signal pathway. | Arsenic Trioxide | ADP ribosylation factor like GTPase 6 interacting protein 5 | Homo sapiens |
| 2 | JWA, a novel retinoic acid-inducible gene, is known to be involved in apoptosis induced by various agents, for example, 12-O-tetradecanoylphorbol 13-acetate, N-4-hydroxy-phenyl-retinamide and arsenic trioxide. | Arsenic Trioxide | ADP ribosylation factor like GTPase 6 interacting protein 5 | Homo sapiens |
| 3 | Herein, our studies demonstrated that treatment of arsenic trioxide produced apoptosis in HeLa and MCF-7 cells in a dose-dependent manner and paralleled with increased JWA expression. | Arsenic Trioxide | ADP ribosylation factor like GTPase 6 interacting protein 5 | Homo sapiens |
| 4 | JWA expression was dependent upon generation of intracellular reactive oxygen species induced by arsenic trioxide. | Arsenic Trioxide | ADP ribosylation factor like GTPase 6 interacting protein 5 | Homo sapiens |
| 5 | Knockdown of JWA attenuated arsenic trioxide induced apoptosis, and was accompanied by significantly reduced activity of caspase-9, enhanced Bad phosphorylation and inhibited MEK1/2, ERK1/2 and JNK phosphorylations. | Arsenic Trioxide | ADP ribosylation factor like GTPase 6 interacting protein 5 | Homo sapiens |
| 6 | Arsenic trioxide induced loss of mitochondrial transmembrane potential was JWA-dependent. | Arsenic Trioxide | ADP ribosylation factor like GTPase 6 interacting protein 5 | Homo sapiens |
| 7 | These findings suggest that JWA may serve as a pro-apoptotic molecule to mediate arsenic trioxide triggered apoptosis via a reactive oxygen species and mitochondria-associated signal pathway. | Arsenic Trioxide | ADP ribosylation factor like GTPase 6 interacting protein 5 | Homo sapiens |