Pub. Date : 2008 Jun
PMID : 18384434
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nuclear factor-kappaB dependency of doxorubicin sensitivity in gastric cancer cells is determined by manganese superoxide dismutase expression. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |
| 2 | In addition, the association between NF-kappaB and manganese superoxide dismutase (MnSOD) in relation to DOX sensitivity was analyzed after the modulation of MnSOD expression. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |
| 3 | In addition, the association between NF-kappaB and manganese superoxide dismutase (MnSOD) in relation to DOX sensitivity was analyzed after the modulation of MnSOD expression. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |
| 4 | Overexpression of mIkappaBalpha or pyrrolidine dithiocarbamate pretreatment decreased the DOX resistance in SNU-601 cells with low MnSOD expression, but not in SNU-216 cells with high MnSOD expression. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |
| 5 | Overexpression of mIkappaBalpha or pyrrolidine dithiocarbamate pretreatment decreased the DOX resistance in SNU-601 cells with low MnSOD expression, but not in SNU-216 cells with high MnSOD expression. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |
| 6 | In comparison, the overexpression of MnSOD, which also suppressed NF-kappaB activation in both cell lines, increased DOX resistance in SNU-601 cells. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |
| 7 | Blocking of MnSOD expression using RNA interference techniques increased DOX sensitivity in SNU-216 cells, which was further augmented by the additional inhibition of NF-kappaB activity. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |
| 8 | Our results showed that whether NF-kappaB contributes to DOX sensitivity in gastric cancer cells is determined by the level of MnSOD expression. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |
| 9 | Thus, targeting both MnSOD and NF-kappaB may be helpful for increasing the efficacy of DOX treatment of DOX-resistant SNU gastric cancer cells. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |
| 10 | Thus, targeting both MnSOD and NF-kappaB may be helpful for increasing the efficacy of DOX treatment of DOX-resistant SNU gastric cancer cells. | Doxorubicin | superoxide dismutase 2 | Homo sapiens |