Title : Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. III. In vitro-in vivo correlation with fluconazole.

Pub. Date : 2008 Jul

PMID : 18381488






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Whereas ketoconazole is often used to study the worst-case scenario for clinical pharmacokinetic drug-drug interactions (DDIs) for drugs that are primarily metabolized by CYP3A4, fluconazole is considered to be a moderate inhibitor of CYP3A4, providing assessment of the moderate-case scenario of CYP3A-based DDIs. Fluconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens