Title : Fructose-fused gamma-butyrolactones and lactams, synthesis and biological evaluation as GABA receptor ligands.

Pub. Date : 2008 Jul 21

PMID : 18378220






1 Functional Relationships(s)
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1 We describe the synthesis of sugar-fused beta-disubstituted gamma-butyrolactones, gamma-butyrolactams and a lipophilic beta-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside. 2-pyrrolidone GABA type A receptor-associated protein Homo sapiens