Title : The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer.

Pub. Date : 2008 May 1

PMID : 18377894






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Gefitinib (IressaR, ZD1839) is a selective epidermal growth factor receptor tyrosine kinase inhibitor that blocks growth factor-mediated cell proliferation and ERK1/2 activation. Gefitinib mitogen-activated protein kinase 3 Homo sapiens
2 Gefitinib (IressaR, ZD1839) is a selective epidermal growth factor receptor tyrosine kinase inhibitor that blocks growth factor-mediated cell proliferation and ERK1/2 activation. Gefitinib mitogen-activated protein kinase 3 Homo sapiens
3 We hypothesized that gefitinib enhances B[a]P-mediated cytotoxicity by decreasing ERK1/2 activation. Gefitinib mitogen-activated protein kinase 3 Homo sapiens
4 Exposure of human lung cancer cells to gefitinib decreased B[a]P-elicited ERK1/2 activation and induced Rad51 protein expression. Gefitinib mitogen-activated protein kinase 3 Homo sapiens
5 Enhancement of ERK1/2 activation by MKK1-CA expression decrease B[a]P- and gefitinib-induced cytotoxicity, and B[a]P-induced mutagenicity. Gefitinib mitogen-activated protein kinase 3 Homo sapiens