Pub. Date : 2008 Jun 1
PMID : 18375193
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR. | Methyl Methanesulfonate | ATR serine/threonine kinase | Homo sapiens |
| 2 | Using ATM- and ATR-defective cells and an ATM specific kinase inhibitor we demonstrate for the first time that the MMS-induced S-phase checkpoint requires both ATM and ATR. | Methyl Methanesulfonate | ATR serine/threonine kinase | Homo sapiens |
| 3 | Using ATM- and ATR-defective cells and an ATM specific kinase inhibitor we demonstrate for the first time that the MMS-induced S-phase checkpoint requires both ATM and ATR. | Methyl Methanesulfonate | ATR serine/threonine kinase | Homo sapiens |
| 4 | These results support the hypothesis that after MMS-treatment, the presence of unresolved BER intermediates gives rise to lesions that activate both ATM and ATR and that during the consequent S-phase delay, such intermediates may be repaired by a recombinational pathway which involves the Rad51 protein. | Methyl Methanesulfonate | ATR serine/threonine kinase | Homo sapiens |