Pub. Date : 2008 May
PMID : 18373075
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells. | Etoposide | BH3 interacting domain death agonist | Homo sapiens |
2 | The role of Bid in etoposide-induced-DNA damage in HCC has not been investigated. | Etoposide | BH3 interacting domain death agonist | Homo sapiens |
3 | Upon the administration of a high dose of etoposide (causing irreparable damage), Bid sensitized cells to apoptosis. | Etoposide | BH3 interacting domain death agonist | Homo sapiens |
4 | However, at a low dose of etoposide (repairable damage), Bid activated the S phase checkpoint through the up-regulation of p21 and p27, which are both p53-independent. | Etoposide | BH3 interacting domain death agonist | Homo sapiens |
5 | In conclusion, our study demonstrates that Bid both exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to different degrees of etoposide-induced DNA damage in HCC cells. | Etoposide | BH3 interacting domain death agonist | Homo sapiens |