Title : Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells.

Pub. Date : 2008 May

PMID : 18373075






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells. Etoposide BH3 interacting domain death agonist Homo sapiens
2 The role of Bid in etoposide-induced-DNA damage in HCC has not been investigated. Etoposide BH3 interacting domain death agonist Homo sapiens
3 Upon the administration of a high dose of etoposide (causing irreparable damage), Bid sensitized cells to apoptosis. Etoposide BH3 interacting domain death agonist Homo sapiens
4 However, at a low dose of etoposide (repairable damage), Bid activated the S phase checkpoint through the up-regulation of p21 and p27, which are both p53-independent. Etoposide BH3 interacting domain death agonist Homo sapiens
5 In conclusion, our study demonstrates that Bid both exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to different degrees of etoposide-induced DNA damage in HCC cells. Etoposide BH3 interacting domain death agonist Homo sapiens