Title : The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2.

Pub. Date : 2008 Jul

PMID : 18372401






3 Functional Relationships(s)
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1 The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2. Prasugrel Hydrochloride carboxylesterase 1 Homo sapiens
2 The presumed role of the human liver- and intestinal-dominant carboxylesterases, hCE1 and hCE2, respectively, in the conversion of prasugrel to R-95913 was determined using expressed and purified enzymes. Prasugrel Hydrochloride carboxylesterase 1 Homo sapiens
3 Hydrolysis of prasugrel by hCE1 showed Michaelis-Menten kinetics yielding an apparent K(m) of 9.25 microM and an apparent V(max) of 0.725 nmol product/min/microg protein. Prasugrel Hydrochloride carboxylesterase 1 Homo sapiens