Pub. Date : 2008 Jul
PMID : 18372401
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2. | Prasugrel Hydrochloride | carboxylesterase 1 | Homo sapiens |
2 | The presumed role of the human liver- and intestinal-dominant carboxylesterases, hCE1 and hCE2, respectively, in the conversion of prasugrel to R-95913 was determined using expressed and purified enzymes. | Prasugrel Hydrochloride | carboxylesterase 1 | Homo sapiens |
3 | Hydrolysis of prasugrel by hCE1 showed Michaelis-Menten kinetics yielding an apparent K(m) of 9.25 microM and an apparent V(max) of 0.725 nmol product/min/microg protein. | Prasugrel Hydrochloride | carboxylesterase 1 | Homo sapiens |