Title : Cyclic adenosine 3',5'-monophosphate responsive element binding protein phosphorylation is required but not sufficient for activation of corticotropin-releasing hormone transcription.

Pub. Date : 2008 Jul

PMID : 18372325






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Forskolin, at threshold concentrations for cAMP production and CREB phosphorylation, induced CRH promoter-driven luciferase activity in 4B cells (EC(50) = 0.7 microm) and CRH primary transcript in hypothalamic neurons (EC(50) = 0.6 microm). Colforsin corticotropin releasing hormone Homo sapiens
2 Forskolin, at threshold concentrations for cAMP production and CREB phosphorylation, induced CRH promoter-driven luciferase activity in 4B cells (EC(50) = 0.7 microm) and CRH primary transcript in hypothalamic neurons (EC(50) = 0.6 microm). Colforsin corticotropin releasing hormone Homo sapiens
3 Similarly, the calcium/calmodulin-dependent kinase inhibitor, KN-93, enhanced PMA plus forskolin-stimulated CREB phosphorylation and inhibited CRH transcription. Colforsin corticotropin releasing hormone Homo sapiens