Title : Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene.

Pub. Date : 2008 Jul 15

PMID : 18372000






4 Functional Relationships(s)
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1 In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 Transfection of CYP1A1 and CYP1B1, but not CYP1A2, suppressed BaP-induced activation of AhR. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
3 These results indicate that CYP1A1 and CYP1B1 play a role in deactivation of BaP on AhR and that CYP1A1 and CYP1A2 are involved in BaP detoxification by suppressing DNA adduct formation. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
4 Dynamic expression of CYP1A1, CYP1A2 and CYP1B1 along with expression of other enzymes such as epoxide hydrolase and phase II enzymes may determine the detoxification or metabolic activation of BaP. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens