Pub. Date : 2008 Jul 15
PMID : 18372000
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
2 | Expression of CYP1A1 and CYP1A2, but not CYP1B1, inhibited DNA adduct formation in BaP-treated HepG2 cells. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
3 | Dynamic expression of CYP1A1, CYP1A2 and CYP1B1 along with expression of other enzymes such as epoxide hydrolase and phase II enzymes may determine the detoxification or metabolic activation of BaP. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |