Title : Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene.

Pub. Date : 2008 Jul 15

PMID : 18372000






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells. Benzo(a)pyrene cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 Expression of CYP1A1 and CYP1A2, but not CYP1B1, inhibited DNA adduct formation in BaP-treated HepG2 cells. Benzo(a)pyrene cytochrome P450 family 1 subfamily A member 2 Homo sapiens
3 Dynamic expression of CYP1A1, CYP1A2 and CYP1B1 along with expression of other enzymes such as epoxide hydrolase and phase II enzymes may determine the detoxification or metabolic activation of BaP. Benzo(a)pyrene cytochrome P450 family 1 subfamily A member 2 Homo sapiens