Title : TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood.

Pub. Date : 2008

PMID : 18371213






2 Functional Relationships(s)
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1 TNF treatment of wild-type mice decreased the SDF-1 concentration in bone marrow extracts and decreased the SDF-1 immunostaining of bone marrow stromal cells, and it also increased the circulating OCP numbers. 5,10,15,20-tetra(3,5-(nido-carboranylmethyl)phenyl)porphyrin tumor necrosis factor Mus musculus
2 Disruption of the SDF-1/CXCR4 axis by TNF may play an important role in mediating OCP mobilization from the bone marrow cavity in chronic inflammatory arthritis. 5,10,15,20-tetra(3,5-(nido-carboranylmethyl)phenyl)porphyrin tumor necrosis factor Mus musculus