Title : Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes.

Pub. Date : 2008 Jun

PMID : 18357586






2 Functional Relationships(s)
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1 Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase. Curcumin mitogen-activated protein kinase 3 Homo sapiens
2 In addition, H2O2 release is essential for Curcumin-mediated ERK1/2 and p38 phosphorylation and HO-1 expression. Curcumin mitogen-activated protein kinase 3 Homo sapiens