Title : Escitalopram regulates expression of TRH and TRH-like peptides in rat brain and peripheral tissues.

Pub. Date : 2008

PMID : 18354249






2 Functional Relationships(s)
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1 We, and others, have previously reported that thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and TRH-like peptides with the general structure pGlu-X-Pro-NH(2), where "X" can be any amino acid residue, have neuroprotective, antidepressant, analeptic, arousal, and anti-epileptic effects that could mediate the neuropsychiatric and therapeutic effects of a variety of neurotropic agents. Proline thyrotropin releasing hormone Rattus norvegicus
2 We, and others, have previously reported that thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and TRH-like peptides with the general structure pGlu-X-Pro-NH(2), where "X" can be any amino acid residue, have neuroprotective, antidepressant, analeptic, arousal, and anti-epileptic effects that could mediate the neuropsychiatric and therapeutic effects of a variety of neurotropic agents. Proline thyrotropin releasing hormone Rattus norvegicus