Pub. Date : 1991 Oct
PMID : 1834679
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GM-CSF in association with IL-1 triggers day-8 CFU-S into cell cycle: role of histamine. | Histamine | colony stimulating factor 2 | Homo sapiens |
| 2 | We further provide evidence that this phenomenon is completely abolished: i) by preventing GM-CSF-induced histamine synthesis by alpha-FMH, the specific inhibitor of histidine decarboxylase (HDC), or ii) by blocking the binding sites of H2 histamine receptors with their specific antagonist oxmetidine. | Histamine | colony stimulating factor 2 | Homo sapiens |
| 3 | In addition, we provide an argument in support of a histamine receptor modulation by GM-CSF that could explain the lack of effect of factor-induced histamine on day-8 CFU-S cell cycling. | Histamine | colony stimulating factor 2 | Homo sapiens |
| 4 | Taken together, our data support the conclusion that IL-1 makes CFU-S sensitive to GM-CSF-induced endogeneous histamine that will trigger them into cell cycle, while GM-CSF alone has no such effect on this biological activity. | Histamine | colony stimulating factor 2 | Homo sapiens |