Pub. Date : 2008
PMID : 18337154
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we investigated the expression and function of plasminogen activator inhibitor (PAI)-1, an inhibitor of the plasminogen activator system and target gene of the transforming growth factor (TGF)-beta1 signalling cascade, in PASMC in IPAH. | pasmc | serpin family E member 1 | Homo sapiens |
| 2 | PAI-1 was also downregulated in primary PASMC derived from IPAH lungs as compared with donor-derived PASMC. | pasmc | serpin family E member 1 | Homo sapiens |
| 3 | In contrast, PAI-1 knock-down with siRNA increased PASMC proliferation and decreased PASMC migration. | pasmc | serpin family E member 1 | Homo sapiens |
| 4 | In contrast, PAI-1 knock-down with siRNA increased PASMC proliferation and decreased PASMC migration. | pasmc | serpin family E member 1 | Homo sapiens |
| 5 | CONCLUSIONS: PAI-1 is significantly downregulated in PASMC in IPAH, on the mRNA and protein level. | pasmc | serpin family E member 1 | Homo sapiens |
| 6 | PAI-1 negatively regulates PASMC proliferation, while it increases PASMC migration. | pasmc | serpin family E member 1 | Homo sapiens |
| 7 | PAI-1 negatively regulates PASMC proliferation, while it increases PASMC migration. | pasmc | serpin family E member 1 | Homo sapiens |