Title : Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression.

Pub. Date : 2008 Apr 2

PMID : 18336843






3 Functional Relationships(s)
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Protein Name
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1 Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression. Benzo(a)pyrene tumor necrosis factor Rattus norvegicus
2 TNF-alpha enhanced induction of CYP1B1, while it simultaneously suppressed the BaP-induced CYP1A1 expression. Benzo(a)pyrene tumor necrosis factor Rattus norvegicus
3 Inhibition of CYP1B1 by fluoranthene significantly decreased both the formation of DNA adducts and the induction of apoptosis in WB-F344 cells treated with BaP and TNF-alpha, thus suggesting that this isoform might be responsible for genotoxic effects of BaP in nonparenchymal liver cells. Benzo(a)pyrene tumor necrosis factor Rattus norvegicus