Title : Polymorphonuclear leukocyte-dependent modulation of platelet function: effect of cloricromene.

Pub. Date : 1991 May 30

PMID : 1833211






1 Functional Relationships(s)
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1 We report here that cloricromene caused a concentration-dependent reduction of platelet aggregation, beta-thromboglobulin (beta-TG) release and cytoplasmic Ca2+ movements induced by PMN stimulated with N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), and enhanced the inhibitory action of unstimulated PMN on platelet responses to the stable endoperoxide analog U46619. N-Formylmethionine Leucyl-Phenylalanine formyl peptide receptor 1 Homo sapiens